From Pharmacology to Diagnostics
In 1995 Prof. Dr. Klaus Kramer and Dr. Tobias Blaschke started to develop an analytical method to non-invasively measure different stages of skin cancer. These efforts, embedded in the context of medical and pharmaceutical research at the Free University of Berlin, aimed at the developement of drug-formulations for skin-cancer treatment. In this context the parelectric properties of different types of tissue proofed to be an excellent criterion to distinguish between normal and abnormal behaviour of the skin surface and the subjacent volume.
First measurments on different excised animal organs and endoscopic inspection of the human vocal cords proofed the reliability and reproducibility of this non-invsive method.
In 2011 parelectrics presented a protoype of the ParaScan I, the first commercially available device for skin cancer diagnostics based on the principle of parelectrics spectroscopy.
Publications concerning the Parelectric Spectroscopy in tumor diagnostics and treatment
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N.B. Wolf, S. Küchler, M.R. Radowski, T. Blaschke, K.D. Kramer, G. Weindl, B. Kleuser, R. Haag, and M. Schäfer-Korting (2009)
Influences of opioids and nanoparticles on in vitro wound healing models
Eur J Pharm Biopharm 2009 http://www.sciencedirect.com/scidirimg/clear.gifdoi:10.1016/j.ejpb.2009.03.009. -
Küchler, S., Radowski, M.R., Blaschke, T., Dathe, M., Plendl, J., Haag, R., Schäfer-Korting, M., Kramer, K.D. (2009)
Nanoparticles for skin penetration enhancement--a comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles
Eur J Pharm Biopharm 2009 (71): 243-250. -
Blaschke, T., Kankate, L. and Kramer, K.D. (2007)
Structure and dynamics of drug-carrier-systems as studied by parelectric spectroscopy
Advanced Drug Delivery Reviews 59 (6): 403-410 -
Stecova, J., Mehnert, W., Blaschke, T., Kleuser, B.,
Sivaramakrishnan, R., Zouboulis, C., Seltmann, H., Korting, H.C.,
Kramer, K.D. and Schäfer-Korting, M. (2007)
Cyproterone Acetate Loading to Lipid Nanoparticles for Topical Acne Treatment: Particle Characterisation and Skin Uptake
Pharmaceutical Research 24 (5):991-1000 -
Braem. C, Blaschke,T., Panek-Minkin,G., Herrmann,W.,
Schlupp, P., Paepenmüller, T., Müller-Goyman, C.,
Mehnert, W., Bittl, R., Schäfer-Korting, M., Kramer, K.D. (2007)
Interaction of drug molecules with carrier systems as studied by parelectric spectroscopy and electron spin resonance
Journal of Controlled Release, 119(1): 128-135 -
Blaschke, T., Sivaramakrishnan, R., Gross, M., and Kramer, K.D. (2006)
Organ mapping using parelectric spectroscopy
Phys. Med. Biol. 51 1623-1631 -
Mahlstedt, K., Blaschke, T., Kramer, K.D. and Gross, M. (2002).
Parelektrische Spektroskopie zur nicht-invasiven Diagnostik von Larynxgewebe.
Biomed Tech (Berl), 47(4):70-75